UK tries out new model for gene testing in cancer patients

By Kate Kelland

LONDON (Reuters) – Britain launched a research programme on Monday that should eventually allow all cancer patients to have access to the kind of genetic analysis that led Hollywood star Angelina Jolie to decide to undergo a double mastectomy.

The project, involving the Institute of Cancer Research (ICR) in London, the U.S. gene sequencing firm Illumina, geneticists and cancer doctors, aims to find a way to allow more cancer genes be tested in more people.

Researchers announcing the 2.7 million pound (2 million pounds) project, funded by the Wellcome Trust medical charity, stressed this was not a response to reports last week of Jolie’s decision to undergo surgery to reduce her breast cancer risk.

“What we’re trying to do here is develop processes that will allow comprehensive and systematic use of genetic information in cancer medicine so that (more people) will be able to benefit from the types of information and situations we were hearing about last week (with the Jolie story),” said Nazneen Rahman, head of genetics at the ICR and a leader on the new project.

Mutations in some genes, known as cancer predisposition genes, greatly increase the risk that a person will get cancer.

Jolie tested positive for a high risk gene mutation that made her about five times more likely to develop breast cancer than women who do not carry this mutation, according to the U.S. National Cancer Institute.

There are nearly 100 other known cancer predisposition genes, but in Britain – where most healthcare is part of the taxpayer-funded National Health Service – testing for them is currently very restricted.

Yet recent advances in reading the genetic code, known as gene sequencing, mean that looking for gene mutations is now faster and cheaper than ever – paving the way for gene testing eventually to become routine for all cancer patients.

“It is very important to know if a mutation in a person’s genetic blueprint has caused their cancer,” Rahman told reporters at a briefing in London.

“It allows more personalised treatment, so for example such people are often at risk of getting another cancer and may choose to have more comprehensive surgery, or may need different medicines, or extra monitoring.”

The programme, called Mainstreaming Cancer Genetics, will use a new Illumina test called TruSight that can analyse 97 cancer predisposition genes within a few weeks for a few hundred pounds, Rahman said.

The new model will be piloted initially in women with breast or ovarian cancer at London’s Royal Marsden hospital, but the team hopes it will in future be used across the country and in many more types of cancer.

($1 = 0.6582 British pounds)

(Reporting by Kate Kelland; Editing by Raissa Kasolowsky)

Source: http://news.yahoo.com/uk-tries-model-gene-testing-cancer-patients-141830759.html

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Sennheiser’s HDVD 800 digital headphone amp now available in the US for $2,000

Analog may be king for audiophiles, but digital is the future, friends, and Sennheiser knows it. That’s why it built the HDVD 800 digital headphone amplifier to improve the sound of your digital tunes, and now stateside listeners can finally get their mitts on the thing. That’s right, folks, a year after it was revealed across the pond alongside its analog brother, Senn’s digital offering’s finally available in the US for just a nickel less than two grand. Folks looking to part with the necessary cash to improve their listening pleasure can do so at the company’s online storefront linked below.

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Source: Sennheiser

Source: http://www.engadget.com/2013/05/21/sennheiser-hdvd-800-digital-headphone-amp-us-availability/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Jordan: Arab Spring paved way for press freedoms

AMMAN, Jordan (AP) ? Jordan‘s prime minister says the Arab Spring has forced governments in the region to allow more freedom of expression and of the press.

Abdullah Ensour said at a meeting of the Geneva-based International Press Institute on Monday that Jordan has “come a long way” in improving both legislation governing press freedoms and the standards of a national media still reeling under long years of state censorship.

“Obviously, we’re not yet where we want to be, but we are determined to continue,” he added.

Jordanian participants at the conference had complained of a controversial press and publications law blamed for significantly restricting press freedoms by placing harsh penalties on violators, ultimately forcing journalists to practice self-censorship.

The IPI began its two-day annual World Congress meeting in Jordan on Monday.

Source: http://news.yahoo.com/jordan-arab-spring-paved-way-press-freedoms-134401526.html

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Paul McCartney kicks off ‘Out There’ tour in U.S.

ORLANDO, Fla. (AP) ? Paul McCartney is kicking off the North American leg of his “Out There” tour in Orlando.

The massive production, which requires 31 trucks’ worth of equipment, includes lasers, huge pyrotechnics, and state of the art video displays, according to the website of the former Beatles star.

McCartney performed the show to a sold-out crowd of 55,000 people in Brazil earlier this month, performing “Band on the Run”, “Hey Jude”, “Yesterday” and “Let It Be.”

He will perform at Orlando’s Amway Center on Saturday and Sunday night. The Orlando Sentinel reports it is McCartney’s only performance in Florida.

At one point during the show, McCartney is raised 20ft above the stage on a special riser as he performs “Blackbird” and “Here Today” acoustically, according to his website.

Source: http://news.yahoo.com/paul-mccartney-kicks-off-tour-us-202549611.html

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Issentiel iPad Leather Case review

There are certain things in life that demand a price premium, such as a 1985 Dom Perignon or Monte Cristo #4, but an Ipad case?? Issentiel of Paris provides a line of smartphone and tablet cases crafted in leather.? The iPad 2 case I received to review lists for $99, which I think qualifies as [...]

Source: http://the-gadgeteer.com/2013/05/19/issentiel-ipad-leather-case-review/

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‘Star Trek’ boldly goes to $84 million at box office

Movies

4 hours ago

Zachary Quinto as Spock and Chris Pine as Kirk in "Star Trek Into Darkness."

Paramount Pictures

Zachary Quinto as Spock and Chris Pine as Kirk in “Star Trek Into Darkness.”

Paramount and Skydance Productions’ “Star Trek Into Darkness” didn’t engage warp speed in its North American opening, but it nevertheless posted a solid four-day debut of $84.1 million.

Overseas, the J.J. Abrams-directed tentpole took in another $40 million over the weekend for an early global total of $164.6 million.

Heading into the weekend, many box office observers believed “Into Darkness” had a shot at hitting $100 million in North America, easily outpacing the $79.2 million of Abrams’ 2009 Star Trek, which reinvigorated the sc-fi film franchise.

VIDEO: “Star Trek Into Darkness” Trailer: The Enterprise Is “Dead”

Paramount vice chairman Rob Moore said he is extremely pleased with the result, particularly overseas, where he says Into Darkness could ultimately double the $127 million earned by the 2009 film. And in North America, he believes word of mouth will be strong, based on the film’s “A” CinemaScore and favorable reviews (the sequel has an 86 percent rating on Rotten Tomatoes, a good score for a commercial tentpole).

“Into Darkness” returns Chris Pine and Zachary Quinto in the roles of Captain James T. Kirk and Spock. Other returning castmembers include Zoe Saldana, Anton Yelchin, Simon Pegg, John Cho and Karl Urban. This time out, a scheming villain played by Benedict Cumberbatch resorts to terrorism to threaten Earth.

13 photos to get you in the mood for “Star Trek Into Darkness”

Paramount and Skydance co-financed the $190 million tentpole, and produced alongside Abrams’ Bad Robot. The script was written by Roberto Orci, Alex Kurtzman and Damon Lindelof.

Source: http://www.today.com/entertainment/star-trek-darkness-boldly-goes-84-million-box-office-1C9984550

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Sexy Cartoon Characters Are The Week’s Biggest News

By Amelia Mularz Disney character Merida from the movie “Brave” got a makeover this week, and loads of parents weren’t having it. The animated heroine got all gussied up in preparation for her induction into the Disney Princess Collection (who knew such pomp and circumstance existed?). Disney released a rendering and it became evident that [...]

Source: http://moviesblog.mtv.com/2013/05/17/merida-brave-controversy/

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Pa. coffee run leads to hatchet hitchhiker arrest

ELIZABETH, N.J. (AP) ? Two cups of coffee ended life on the run for an Internet sensation known as Kai the hatchet-wielding hitchhiker.

An employee at a Starbucks in Philadelphia is credited with recognizing 24-year-old Caleb “Kai” McGillvary, whose fledgling celebrity took a turn toward notoriety when authorities announced this week that he was wanted in the beating death of a New Jersey lawyer three times his age.

The unlikely pair met amid the neon lights of New York City’s Times Square over the weekend and headed back to the squat brick home of 73-year-old Joseph Galfy Jr. on a quiet cul-de-sac in suburban Clark, N.J., authorities say. On Monday, Galfy was found beaten to death in his bedroom, wearing only his socks and underwear. McGillvary was arrested Thursday shortly after leaving the Starbucks and charged with killing Galfy.

McGillvary gained a measure of fame in February after intervening in an attack on a California utility worker. In an interview viewed millions of times online, he described using a hatchet he was carrying to repeatedly hit a man who had struck a worker with his car, fending off a further attack, and thus became known as “Kai the hatchet-wielding hitchhiker.”

Galfy’s funeral was held Friday in a small stone chapel in Warren, N.J. He was buried in East Hanover.

Galfy was an “excellent land use attorney,” said friend Robert Ellenport. He said Galfy loved to travel and was a fan of the New York Giants and the Seton Hall University basketball team. Galfy would fly to warmer climes to watch Seton Hall play its first games of the season and was urging Ellenport and his partner to travel to Bali, one of Galfy’s favorite vacation spots.

The victim’s sister-in-law, Diane Galfy, said at her home that “he was a very well-respected man. That’s what we want people to know,” she said. She said her husband didn’t want to talk and her children were devastated.

Galfy was a respected lawyer who in recent years handled land use and domestic violence cases, according to Union County Prosecutor Theodore Romankow, whose office is prosecuting McGillvary. The two knew each other through legal circles.

“He was just a nice man, a gentle man, well-regarded in the community,” Romankow said.

In addition to his law practice, Galfy was the attorney for the planning board in Green Brook, N.J., and played drums in a wedding band.

Authorities said McGillvary was arrested Thursday evening after he walked into a Starbucks near a bus station in downtown Philadelphia and ordered two coffees. The woman who served McGillvary recognized him and alerted her manager, who called the police.

McGillvary took off before police arrived, Philadelphia Police Commissioner Charles Ramsey said, and without his coffee. But an officer went to a nearby bus terminal and found McGillvary, who was arrested there.

“He wasn’t lying low,” Romankow said. “He was out there.”

McGillvary was arraigned Friday and being held without bail on charges in Galfy’s killing, though a court official said he has a U.S. Immigrations and Customs Enforcement detainer for three arrests in Canada in recent years. ICE officials did not immediately return a request to confirm the detainer. It’s not clear whether McGillvary would be deported rather than sent to New Jersey to face prosecution in Galfy’s death.

Romankow said that McGillvary, who said in his TV appearance he prefers to be called “home-free” instead of homeless, traded on his newfound prominence to meet fans across the country.

Those fans include Terry Ratliff, 32, of Kingsland, Ga., who said he spoke to McGillvary a few times recently about working on music with him. Ratliff said he made about $70 from a YouTube video featuring McGillvary and sent him $34 on May 8. Ratliff said McGillvary was in New York at the time.

The two haven’t met, but Ratliff started a fund for McGillvary’s legal defense that has only raised $66 so far. It’s not clear whether McGillvary has a lawyer, and the public defender’s office in Philadelphia had no record of him.

“If he is telling the truth, then maybe better legal representation will help get that truth out,” Ratliff said.

McGillvary has made statements before, though, that don’t add up.

He has said he is from Sophia, W.Va., but Mayor Danny Barr said Friday that he and the fire chief know everyone in the town of 1,334, have never heard of him and found nothing about him in town records.

McGillvary also wrote statements on Facebook following Galfy’s death that were “sexual in nature,” Romankow said, and noted that they could have been self-serving.

McGillvary’s last post, dated Tuesday, asks “what would you do?” if you awoke in a stranger’s house and found you’d been drugged and sexually assaulted. One commenter suggests hitting him with a hatchet, and McGillvary’s final comment on the post says, “I like your idea.”

Ratliff says he is the commenter McGillvary was responding to. He said he had sent McGillvary an email the night before the post saying he had a song idea for him. Ratliff says when McGillvary responded with “I like your idea,” on Facebook, Ratliff wasn’t sure if McGillvary was referring to his email about music or suggestion to beat up the man.

It was a hatchet that helped give McGillvary a brief taste of fame in February when he gave a rambling, profanity-laced interview to a Fresno, Calif., television station about thwarting an unprovoked attack on a Pacific Gas & Electric employee. The interview went viral, with one version viewed more than 3.9 million times on YouTube. McGillvary later traveled to Los Angeles to appear on ABC’s “Jimmy Kimmel Live!”

Noting that his photo had been all over, Ramsey said it apparently wasn’t difficult to recognize McGillvary.

“Being on YouTube too much,” the police commissioner said, “is not always a good thing.”

___

Contributing to this report were Associated Press writers Kathy Matheson in Philadelphia; Vicki Smith in Morgantown, W.Va.; and Rema Rahman in Trenton, N.J.

Source: http://news.yahoo.com/pa-coffee-run-leads-hatchet-hitchhiker-arrest-171038273.html

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Amy's Baking Company Hires PR Firm Of Joe Arpaio | The Braiser

After finding themselves the butt of online jokes following their appearance on Kitchen Nightmares, and after posting a massive, all-caps meltdown against the ?Reddits? on Facebook, Amy and Samy Bouzgalo have hired Rose, Moser & Allyn, a Scottsdale, AZ public relations firm, to restore what morsels of a good name they have left at Amy?s Baking Company. The Internet should brace itself, because those wacky Bouzgalos might remain in business for a damn long while thanks to the work of these guys.

How good is Rose, Moser & Allyn? They represent the highly controversial Maricopa County Sherrif Joe Arpaio, the law enforcement official?so divisive that someone recently tried to blow him up with a package bomb. Time Magazine?describes him thusly:

The 80-year-old lawman, who?describes?himself?as ?America?s toughest sheriff,? has served for the past two decades and is best known for the tough talk that made him a centerpiece of the undocumented immigration debate. He has logged more than 35,000 arrests of people who were?accused?of?being in the country illegally. So staunch was his position that the Department of Justice investigated him for racial profiling in 2010.? He?s?also?built?open-air?tent?cities?to house prisoners at a cheaper cost to?the?county?and?ordered that inmates? uniforms be changed to?pink?because he felt that the color would be psychologically calming to them.

Frankly ? and we say this with the utmost sincerity ? it might be easier to represent a hardline, anti-immigration extremist than a couple who claims that their children inhabit cat bodies. Nevertheless, given the brief bio above, Arpaio and the Bouzgalos don?t seem that many degrees apart: at some point, the Bouzgalos would have totally started keeping their ejected customers in tent cities.

As their first PR move, Rose, Moser & Allyn got the Bouzgalos to stage a grand re-opening for next Tuesday, with a press conference and a limited seating dinner, where customers can ?judge for themselves the character of owners Amy and Samy? who have devoted their lives to, and earn their living from, their small restaurant.? (That?s from the press release written by the PR firm. Isn?t it a good one? It?s so heartstring-tuggy, and such.)

[ABC15]

Source: http://www.thebraiser.com/amys-baking-company-hires-joe-arpaio-pr-firm/

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Nokia Lumia 928 for Verizon hands-on

Nokia Lumia 928 for Verizon handson

The Lumia 928 isn’t the first of Nokia’s Windows Phone 8 handsets to hit Verizon — that distinction goes to the 822 — but for all intents and purposes, it’s the first true flagship Lumia to bear Big Red’s branding. From the jump, you’ll note that Nokia’s bent somewhat to Verizon’s heavy hand, customizing the 928 in a way that shucks the smooth polycarbonate unibody of the 920 for something more hard-edged and angular, yet still plastic. So, what’s so new about this Lumia? Apart from its Xenon flash, nothing at all. It bears the same 4.5-inch, 1,280 x 768 PureMotion HD+ display (now, OLED), 1.5GHz dual-core Snapdragon S4 processor with 1GB RAM, 2,000 mAh battery, integrated wireless charging, NFC and 1.2-megapixel front-facing / 8.7-megapixel rear camera setup as the Lumia 920. Naturally, the 928′s made to run on Verizon’s network, so you’ll find support for LTE / CDMA, but there are also radios for HSPA+ making it “global ready.” We’ll have a review for this deviant Lumia coming shortly, but in the meantime follow along for our first impressions.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/lk71YvZCCH4/

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